An individual with a high caffeine intake may have increased susceptibility to:

Increased susceptibility to premature ventricular contractions (PVCs) is linked to high caffeine intake due to the stimulant effects of caffeine on the cardiovascular system. Caffeine can enhance myocardial excitability and increase the likelihood of ectopic foci within the ventricles, which can lead to the occurrence of PVCs. PVCs are abnormal heartbeats originating in the ventricles and are commonly associated with increased sympathetic nervous system activity and heightened levels of circulating catecholamines, both of which can be influenced by caffeine consumption.

Caffeine has also been shown to affect sodium and calcium influx into cardiac cells, which can disrupt the normal electrical conduction pathway and lead to irregular heartbeats. This connection helps explain why individuals with high caffeine intake might experience more frequent PVCs compared to those with lower intake levels. While other arrhythmias may occur with excessive caffeine, the direct correlation between high caffeine consumption and an increase in PVCs is particularly well-documented.